FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Krüppel-like factor 2
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چکیده
منابع مشابه
FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2.
AIMS Krüppel-like factor 2 (KLF2) is implicated as a key molecule maintaining endothelial function. This study was designed to evaluate the reciprocal regulation of KLF2 by the forkhead transcription factor FOXO1, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions. METHODS AND RESULTS Exposure of human umbilical vein endothelial cells ...
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Krüppel-like Factor 2 (KLF2) is a 38-kDa transcription factor that is highly expressed in the vascular endothelium. The enormous attention that KLF2 has received in recent years is well deserved, because experimental evidence has shown that it is a vital protein that, via transcriptional and nontranscriptional targets, mediates a host of endothelial functions.1 These include inhibition of vascu...
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OBJECTIVE To evaluate if p53 decreases Kruppel-Like Factor 2 (KLF2) expression and determine whether p53-mediated suppression of KLF2 plays a role in p53-induced endothelial dysfunction. METHODS AND RESULTS Endothelial KLF2 mediates endothelium-dependent vascular homeostasis by differentially regulating endothelial genes, leading to an anti-inflammatory and antithrombotic endothelial surface ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvs283